Synthetic Chemistry

Piramal Discovery Solutions (PDS) is a reputed service provider for mg to kg scale discovery chemistry requirements . We have partnered with a range of well known pharmaceutical and biotechnology companies from Europe, USA and Japan.

The specialized team at PDS has a broad array of experience in preparing small molecule NCEs with the requisite high quality specifications. It is proficient in developing methodologies, including the synthesis of singles, multi-step, small arrays as well as focused libraries. Our scientific team is also experienced in the design of focused libraries for use in hit-to-lead and lead optimization projects.

The delivery of all our compounds is accompanied with complete characterization data including, but not limited to, high-field NMR, mass and purity by LC-MS/HPLC/GC. We have also recently installed Supercritical Fluid Chromatography to aid chiral separation and generate a higher throughput. Access to the scientific literature (ACS amongst others ) and databases such as SciFinder and Reaxys provides the team with all the necessary up to date information to modify and develop new synthetic routes.

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Pharma Services Offered

  • Synthesis of discrete compounds/focused series, building blocks, common intermediates
  • Scale-up of intermediates and final compounds (up to multiple hundred grams)
  • Synthesis or reference standards/impurities
  • Route finding and Route scouting activities

Chemistry Capabilities

  • Chiral chemistry
  • Aliphatic, aromatic and heterocyclic chemistry
  • Carbohydrate chemistry
  • Peptide chemistry
  • Steroid chemistry
  • Nucleoside chemistry
  • Natural product chemistry
  • Microwave Chemistry

Other Offerings

Discovery Chemistry

In-vitro ADME Service

Non-GMP Kilo lab

Analytical Support Services

Piramal Discovery Solutions (PDS) is a reputed service provider for mg to gm scale discovery chemistry. We have partnered with a range of well known pharmaceutical and biotechnology companies from Europe, USA and Japan.

In vitro facilities at PDS provide ADME (absorption, distribution, metabolism, excretion) services to provide faster and improved decision making points for our Chemistry clients or standalone offering to support drug discovery programs.

Piramal’s fully-equipped kilo-lab allows for rapid development of scalable and robust chemical processes using advanced process methodologies to provide a quick supply in the early phase of the development.

When you send PDS your chemistry work, you want to be assured that the allocated chemist(s) are fully focussed on the delivery of your chemistry. PDS achieves this through our “High Speed Delivery” process, a core element of which is our analytical support.

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