In-Vitro Biology – A growth story

Speed and accuracy with In vitro biology studies, along with rapid synthesis of novel, quality, drug discovery chemistry targets, play a critical role in rapidly advancing preclinical programs into the clinic. Established in year 2009, the in vitro biology department at Piramal Enterprises Limited, Discovery Solutions facility, in Ahmedabad, Gujarat, India has grown from a chemistry support function, to an independent service vertical, serving multitudes of customers, developing tailor-made assays, and screening thousands of novel molecules every year.

As the department evolved, Piramal has invested and upgraded infrastructure to support several hit-to-lead and lead optimization collaborations simultaneously, with, small, medium, and large biotech companies. Presently, Piramal offers a comprehensive array of services including physicochemical screening, permeability, protein binding, drug metabolism, drug-drug interaction, cell/enzyme based and biochemical screens. The rapid growth in customers and the service offerings have been managed effectively by instrument sophistication, increased automation, miniaturizing of assays, optimizing analyses time, and upgrading to better data management software.

A typical case study: In 2015, a program from a large biotech was awarded to Piramal, which had some daunting challenges. One of the key objectives was to develop and validate a number of assays, while maintaining high throughputs under tight deadlines. The in vitro department made a commitment to the client to meet their objectives and worked through an innovative multi-shifts/day approach to deliver per the timelines. With an average turnaround time of just 7 days per compound for 7 different studies, and screens that included 1200 such compounds over the first year of contract, the Customer Satisfaction Index (CSI) from the client was 93% of the maximum achievable. Even more importantly, the client renewed the contract on in vitro biology, but this time, expanded to include discovery chemistry also as part of the partnership.

Piramal Enterprises Limited, Discovery Solutions’ in vitro biology department now has grown to become a partner of choice for both big pharma and biotech, by combining a state-of-the-art infrastructure with its focus on commitment towards customers. With a talented team of scientists, an excellent track record of delivering quality data to meet the most aggressive of timelines, and a focus on customer centricity, the PPS in vitro biology team looks forward to assisting you with discovering and developing the next generation of breakthrough therapies. For more information on how the in vitro can help you on speed and costs, please contact us at contactus@piramal.com

Great!